Effect of acetylsalicylic acid on arterial stiffness in pregnancy in a Colombian population: prospective cohort study
Keywords:
Aspirin, Vascular Stiffness, Preeclampsia, Induced Hypertension in PregnancyAbstract
To estimate the effect of acetylsalicylic acid consumption on hemodynamic variables and arterial stiffness at different times of gestation and the development of hypertensive disorders. Methods: Prospective cohort study included 1800 women with pregnancies of 17 weeks or less, with no history of hypertension; 487 (27%) received 100 mg/day of acetylsalicylic acid before week 16. The variables were measured at four points of gestation. The effect of consumption was estimated using the model of generalized estimable equations, adjusted for confounding variables. Results: Baseline levels of the variables were higher in the group receiving acetylsalicylic acid, but with no difference in the rate of change when adjusted. The adjusted differences in aortic increase index, pulse wave velocity, central aortic systolic pressure, systolic blood pressure, and mean arterial pressure, between patients who consumed acetylsalicylic acid and those who did not consume was 0.5% (-0.2, 1.3); 0.1 m/s (-0.02; 0.1), 0.9 mm Hg (-0.1; 1.8), 0.7 mm Hg (-0.2, 1.6) and 0.6 mm Hg (-0.2, 1.4), respectively. In patients who received acetylsalicylic acid and developed preeclampsia, an adjusted average increase of 0.3 m/s (95% CI 0.1, 0.5) was found between each measurement of pulse wave velocity. Conclusions: In women who received acetylsalicylic acid and developed preeclampsia, an increase in the adjusted average change in pulse wave velocity was found, indicating that consumption of acetylsalicylic acid did not decrease arterial stiffness.
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References
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