Uso de factores de crecimiento plaquetario en síndrome genitourinario. Experiencia privada

Authors

Keywords:

Factores de Crecimiento Plaquetario Autologos, Síndrome Genitourinario, SGM, Autologous Platelet Growth Factors, Genitourinary Syndrome

Abstract

To evaluate the effectiveness of the use of autologous platelet growth factors in long-term menopausal genitourinary syndrome. Methods: A prospective, longitudinal, observational, experimental study was conducted in 1500 patients who attended the private practice from August 2012 to December 2016, with signs and symptoms compatible with menopausal genitourinary syndrome. With prior informed consent, medical history, physical examination, paraclinical examination (laboratory, cytocolposcopy, vault or cervical biopsy) and classification of menopausal genitourinary syndrome into mild, moderate and severe, cervix biopsy was taken from those considered severe. Platelet-rich plasma was prepared and placed on each patient monthly for three sessions. Controls were performed at one month, at 45 days (cytology, colposcopy and control biopsy in cases classified as severe), at six months and one year after the procedure, and then, they went to the gynecological control annually until today. Results: The symptomatology consulted was variable, predominantly pruritus, and vaginal discharges in 80%. In 100% of the patients, the symptoms disappeared. There were no complications. of the procedure. 3% reported headaches, and transient hyperthermia. There were significant histological changes in biopsy and control cytology.
Conclusions: The use of autologous platelet growth factors contributes to restoring the vaginal mucosa, with the consequent disappearance of the symptoms. It is a minimally invasive tool, without side effects.

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References

Alcaraz-Rubnio J, Oliver-Iguacel A, Sánchez-López JM. Nuevo método de obtención de plasma rico en factores de crecimiento plaquetario (PRP). Estudio descriptivo en 15 pacientes y comparacion con los resultados publicados en la bibliografía. Rev Hematol Mex [Internet]. 2015 [consultado 15 de agosto de 2017]; 16(3):210-216. Disponible en: https://www.medigraphic.com/pdfs/hematologia/re-2015/re153d.pdf

Portman DJ, Gass ML; Vulvovaginal Atrophy Terminology Consensus Conference Panel. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women’s Sexual Health and the North American Menopause Society. Menopause. 2014; 21(10):1063-1068. doi: 10.1097/GME.0000000000000329.

Angulo Rujano FE, Calderón Ruiz LC, Turri Rossana. Síndrome genitourinario en la menopausia: tratamiento con plasma rico en plaquetas. Rev ObstetGynec Venez [Internet]. 2017 [consultado 26 de agosto de 2017]; 77(3):204-211. Disponible en: http://www.sogvzla.org.ve/sogvzla20186/cms/svcobtenerpdfrevista.php?id=0000000086&tipo=normal&fila=8

Carrillo-Mora P, Gonzalez-Villalva A, Mascias-Hernandez S, Pineda-Villaseñor C. Plasma rico en plaquetas . Herramienta versátil de la medicina regenerativa? Cir Cir [Internet]. 2013 [consultado 28 de agosto de 2017]; 81(1):74-82. Disponible en: https://www.medigraphic.com/pdfs/circir/cc-2013/cc131m.pdf

Conde Montero E, Fernández Santos M, Suárez Fernandez R. Plasma rico en plaquetas: aplicaciones en dermatología. Actas dermosifiliogr [Internet]. 2015 [consultado 15 de agosto de 2017]; 106(2):104-111. Disponible en: https://www.actasdermo.org/es-plasma-rico-plaquetas-aplicaciones-dermatologia-articulo-S0001731014001793

Bachmann GA, Notevolitz M, Kelly SL, Thompson C. Long-term non-hormonal treatment of vaginal dryness. Clin Pract Sex [Internet]. 1992 [consultado 26 de agosto de 2017]; 8(8-9):3–8. Disponible en: https://www.replens.com/en-ca/Documents/Long_Term_Non-Hormonal_Treatment_of_Vaginal_Dryness.pdf

Anitua E, Sánchez M, Orive G, Andía I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007 Nov;28(31):4551-60. doi: 10.1016/j.biomaterials.2007.06.037.

Nisbet OH, Nisbet C, Yarim M, Ozak A. The efficacy of platelet-rich plasma gel and topical estradiol alone or in combination on healing of full-thickness wounds. Wounds [Internet]. 2009 [consultado 15 de agosto de 2017]; 21(7):183-191. Disponible en: https://www.hmpgloballearningnetwork.com/site/wounds/issue/volume-21-issue-7-july-2009

Published

2022-08-31

How to Cite

Ajakaida, R. (2022). Uso de factores de crecimiento plaquetario en síndrome genitourinario. Experiencia privada. Revista De Obstetricia Y Ginecología De Venezuela, 82(2), 198–206. Retrieved from http://saber.ucv.ve/ojs/index.php/rev_ogv/article/view/24350

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Trabajos Originales