Relationship between Paraoxonase and Malondialdehyde as a marker of oxidative stress in patients with psoriasis

Abstract

Oxidative stress plays an important pathogenetic role in Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous and endogenous factors. Therefore, the aim of the present study was to compare Paraoxonase (PON1), and malindialdehyde (MDA) in patients and in healthy age-matched subjects, taking into account biochemical correlates. The study was carried out in the two age-matched groups of men. Group I consisted of 50 psoriatic patients aged (34.8–77.0) years.

Results: A total of 50 patients (46 women and 74 men) and 40 healthy gender- and age-matched controls were enrolled in the study. Increased lipid peroxidation (MDA) (339.86± 29.97 vs 229.39± 13.85: < .001). as well as downregulated PON activity (0.92± 0.09 vs1.37± 0.29: < .001) were found in psoriatic patients compared with controls. Receiver operator characteristic curve investigation shown the levels of PON and MDA are the best biomarkers differentiating subjects with psoriasis. Furthermore, a significant negative correlation was found between PON and MDA, with a moderate effect size correlation coefficient of -.34 (p =.014, 95 % Confidence interval = [-.57, -.07]). This implies that MDA has a tendency to decrease as PON increases.

Conclusion: This study indicates that serum PON1 together with MDA, is a useful and novel marker for evaluating the disease status and activity of patients with Psorasis.