Estimation of lipid profile in younger patients suffering from diabetic mellitus type 1

Abstract

Background: Dyslipidemia and hyperglycemia are metabolic anomalies ordinarily found in youthful patients with Type 1 diabetes mellitus (T1DM) and both increment the danger of cardiovascular illness, objective: to estimated lipid profile in younger patients and effected of these lipids on DMT1. Methods: case control study of (75) younger patients were divided in to three groups according to HbA1C, (25) younger patients with high HbA1C (> 7.5 HbA1C) suffering from DMT1, (25) younger patients with moderate HbA1C (≤ 7.5 HbA1C) and (25) younger patients as control healthy, were with age range from 10 to 19 years who attended Changing Diabetes in Children. The younger patients were visit to clinical provides. All patients and control were from the same ethnic group (Arabic). Blood samples collected from each patients; lipid profile tests made for each blood sample to estimated Cholesterol, Triglyceride, HDL, LDL, and VLDL and compared them between study groups. Results: HbA1C, Glycemic control between groups compared and HbA1c was significantly (P = 0.001) higher in dyslipidemia group. The mean fasting blood glucose was also significantly higher in dyslipidemia group (P 0.0001). The mean differences of lipid profile (mg/dl) (Cholesterol Triglyceride, HDL, LDL, VLDL) according to study groups including (25 younger patients as Control group, younger patients with high HbA1C (> 7.5 HbA1C) suffering from DMT1, and (25) younger patients with moderate HbA1C (≤ 7.5 HbA1C) was investigated. significant differences between means of lipid profile according to study group (P 0.001). Conclusion: Adolescent patients, which have DMT1, have abnormal lipid profile level and abnormal lipoprotein building. Then after grown up glycemic control is a significant become abnormal.