Uric acid is an independent biomarker in the management of a chronic renal disease

Abstract

Background. Several studies have documented uric acid as a predictor of decreased glomerular filtration rate. However, this relationship remains unclear in terms of renal disease progression. 

Objectives. Evaluate the association of uric acid with the decrease in glomerular filtration rate in the progression of chronic kidney disease in adult patients. Methods. For this, we worked with 361 patients (132 women and 229 men) diagnosed with chronic kidney disease, corresponding to the period January 2019 - January 2020.

Results. The main risk factors reported were diabetes mellitus (35%), hypertension (24%) and diabetic nephropathy (10%). Correlational analysis in the general population and women in baseline UA indices correlated negatively with eGFR (r= -0.138, p= 0.009; r= -0.300, p<0.001, respectively), while in men we observed no significant correlation (r = -0.041, p= 0.539).

Conclusion. Recent evidence from this study showed UA as an independent biomarker with a significant correlation between uric acid levels and renal function concerning gender. Increased UA is associated with decreased eGFR and its progression in CKD with a higher risk in women than men.