Effect of endurance training with selenium on IL-17 and IL-18 in heart tissue in rats exposed to cadmium poisoning

Abstract

Interleukin-17 (IL-17) and interleukin-18 (IL-18) are Proinflammatory cytokines. The mainpurpose of this study is analysis of the effect ofendurance training, along with using selenium, on IL-17and IL-18 in heart tissue of rats exposed to cadmium poisoning.in this empirical study, 30 Sprague Dawley maleRats were selected and placed randomly in 6 groups with5 rats in each group: 1) control 2) sham 3) cadmium4) selenium with cadmium 5) endurance training withcadmium and 6) endurance training with selenium andcadmium. During 8 weeks, the rats in groups 3, 4, 5 and6 took 2mg/kg peritoneum cadmium daily. Groups 4 and6 used 0.23mg/kg selenium daily and groups 5 and 6done endurance practices 3 sessions per week. For analysisof the data, Kolmogorov-Smirnov test, independentt-test and two-way ANOVA were used (p≤0.05). 8 weeksof endurance training and 8 weeks of using seleniumcould leave significant effect on reduction of IL-17 andIL-18 expression of rats poisoned by cadmium (p=0.001).Moreover, the interactive effect of endurance trainingand using selenium on reduction of IL-17 and IL_18 expressionin rats poisoned by cadmium was significant(p=0.001). 8 weeks of using selenium with endurancetraining could improve proinflammatory cytokines in ratspoisoned with cadmium.