Association of polymorphisms of cardiovascular system genes with idiopathic recurrent pregnancy loss of Kazakh populations

Abstract

The interrelation of polymorphic variants of coagulationand cardiovascular system geneswas studied: MTHFR (C677T, A1298C), MTR(А2756G), MTRR (A66G), F5 (А506G), F2 (G20210А),FGB (G455A), ITGB3 (Leu33Pro), PLANH1 (5G/4G); GPIa(C807T), AGTR1 (A1166C), ACE (I/D), eNOS (Glu298Asp)with development of idiopathic form of recurrent pregnancyloss (iRPL) in ethnically homogeneous populationof the Kazakhs. The results of independent replicativeTaqMan genotyping of 302 patients with iRPL and 300women with normal reproduction did not reveal an associationof studied polymorphisms with the developmentof iRPL in the Kazakh population.