Sensibilidad a la Sal y Tiempo de Obesidad
Palabras clave:
Sal sensible, Obesidad, Insulina, Tolerancia oral a glucosa, Salt sensitivity, Obesity, Insulin, Oral glucose tolerance testResumen
Objetivo: Establecer si existen diferencias en el tiempo de obesidad entre los sujetos sensibles a la sal (SS) y resistentes a la sal (SR) y relacionarlas con diversos parámetros cardiometabólicos. Sujetos: SR (n= 25) y SS (n=31). Pacientes y Métodos tiempo de evolución de la obesidad. Resultados mL, p< 0,05), para los SR y SS respectivamente. Conclusión adquirir el fenotipo SS y uno de los primeros cambios cardiometabólicos en manifestarse puede ser la respuesta alterada ante una sobrecarga oral de glucosa.
Abstract SALT SENSITIVITY AND OBESITY DURATION
Objective: To establish the difference in obesity duration among salt sensitive (SS) and salt resistant (SR) subjects, and to correlate with several cardiometabolic parameters. Patients and Methods: SR (n = 25) and SS (n = 31). Biochemical assays; we measured fasting glycemia, lipid profile and glucose tolerance test. Clinical evaluation of body mass índex (BMI), waist circumference (WC), blood pressure (BP), heart rate (HR) and obesity duration in years. Results: There were significant differences in obesity duration (3.6 ± 1.4 vs. 8.7 ± 1.7 years, p <0,04) and insulin levels after 2 hours of 75 g oral glucose load (58.0 ± 5.45 vs. 72.6 ± 6.98 µU/mL, p <0.05), for SR and SS respectively. Conclusion: Most probably it is necessary a longer time of obesity evolution to acquire the SS phenotype; an altered response to the oral glucose load test seems to be the first cardiometabolic change linked to conversion to the SS phenotype.
