Listeria monocytogenes and Trojan horse mechanism across the blood-brain barrier
DOI:
https://doi.org/10.37910/RDP.2024.13.1.e389Keywords:
Listeria monocytogenes, Monocitos, Macrófagos, Quimiotaxis, Barrera HematoencefálicaAbstract
Central nervous system infections are life- threatening, caused by pathogens such as bacteria, viruses and fungi. To access the brain, microorganisms use
various mechanisms. Listeria monocytogenes is a short, flagellar and intracellular gram-positive bacterium, with the ability to induce its internalization in phagocytic (monocytes/macrophages) and non-phagocytic (endothelial cells) cells. By infecting macrophages, these microorganisms take advantage of their binding, adhesion, and transendothelial migration capacity to cross the blood-brain barrier, finally generating bacterial meningitis. In this review we describe the Trojan horse mechanism used by Listeria monocytogenes to invade the brain in the development of infectious diseases and we incorporate new knowledge about molecules that intervene in this mechanism.
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