Virus de papiloma humano y lesión intraepitelial cervical en adolescentes embarazadas

Lissette Mendoza; Jose Urdaneta; Chiquinquira Silva; Isabel Maggiolo; Nasser Baabel; Richard Mejía

Authors

Lissette Mendoza Departamento de Obstetricia y Ginecología. Escuela de Medicina. Facultad de Medicina. Universidad del Zulia. Maracaibo,
Jose Urdaneta Departamento de Morfofisiopatología. Escuela de Bioanálisis. Facultad de Medicina. Universidad del Zulia. Maracaibo,
Chiquinquira Silva Departamento de Ciencias Morfológicas. Escuela de Medicina. Facultad de Medicina. Universidad del Zulia. Maracaibo,
Isabel Maggiolo Departamento de Obstetricia y Ginecología. Escuela de Medicina. Facultad de Medicina. Universidad del Zulia. Maracaibo,
Nasser Baabel Departamento de Obstetricia y Ginecología. Escuela de Medicina. Facultad de Medicina. Universidad del Zulia. Maracaibo,
Richard Mejía Departamento de Obstetricia y Ginecología. Escuela de Medicina. Facultad de Medicina. Universidad del Zulia. Maracaibo,

Keywords:

Adolescents, Pregnancy, Genotyping, squamous Intraepithelial Lesion, Human papillomavirus.

Abstract

Aim: To compare the presence of Human Papilloma Virus (HPV) and Squamous Intraepithelial Lesion (SIL) in pregnant and non-pregnant adolescents treated at the “Maternidad Dr. Armando Castillo Plaza” in Maracaibo, Venezuela. Patients and Methods: A comparative research with non-experimental transectional and field design was performed; where 46 pregnant adolescents (cases) and 46 non-pregnant adolescents (controls) was included, chosen by random probability sampling, who underwent identification of factors associated with the pathology, evaluation by pap-smear and HPV genotyping by chain reaction of polymerase (PCR). Results: It was found that 32.6% of pregnant women had low grade SIL ( HPV or CIN 1) compared to 21.7% in non-pregnant women, with a risk twice higher (OR [95% CI] = 2.44 [1.05 -5.65]). The molecular diagnosis was positive in half of the total sample, being higher in pregnant women (52.1 vs. 47.9p <0.05); infections with high-risk genotypes predominated 47.8 vs 30.5; p <0.05). HPV 16 was the most prevalent among pregnant women (21.7%) and co-infection by low-risk genotypes (6-11) in non-pregnant women (17.4%). Conclusions: adolescent pregnant women have a higher prevalence of LIE and genital HPV infection, associated with a significant risk of twice the probability of presenting an LIE compared to non-pregnant adolescents.

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