Cáncer de próstata y polimorfismos de la glutation s-transferasa en una población venezolana

Miriam Angeli-Greaves; Jon Garate; Maria Gabriela Pérez Pereda; Elizabeth Viera; Marcel Yibirin; Selene Harrisson; Marycarmen Chacín

Authors

Miriam Angeli-Greaves Escuela de Medicina Luis Razetti, Facultad de Medicina. Universidad Central de Venezuela
Jon Garate Hospital Universitario de Caracas
Maria Gabriela Pérez Pereda Hospital Universitario de Caracas
Elizabeth Viera Escuela de Medicina Luis Razetti, Facultad de Medicina. Universidad Central de Venezuela
Marcel Yibirin Escuela de Medicina Luis Razetti, Facultad de Medicina. Universidad Central de Venezuela
Selene Harrisson Facultad de Farmacia. Universidad Central de Venezuela
Marycarmen Chacín Laboratorio de Hematología, Instituto Anatómico

Keywords:

Glutathione S-transferase, prostate cancer, risk factors, polymorphism

Abstract

Introduction: Prostate cancer presents with a high incidence in the Venezuelan population. There is no known genetic pattern related to the expression of drug metabolizing enzymes Glutathione S-transferases. Methods: We proceeded to study the possible correlation between null polymorphism for these enzymes and prostate adenocarcinoma. The sample included 100 patients recruited from the Urology Department of three University Hospitals in Caracas, Venezuela, 50 cancer patients and 50 cancer free controls. Blood samples were drawn from each patient and polymorphisms for Glutathione S-transferase Mu 1 (GST M1) and Glutathione-sS-transferase Theta 1(GST T1) were determined by polymerase chain reaction from lymphocytes. Results: Null genotype was found in 40% and 24% of cancer patients whereas the percentage in controls was 38 and 22% respectively, showing no statistically significant differences between the two groups. Conclusions: It was not possible to show a significant difference between the two groups. Recommendations: Due to the small size of the sample, it would be necessary to explore further in a larger population sample to determine whether there is an association between the expression of these enzymes and prostate cancer.

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