EXPRESIÓN DE MOLÉCULAS DE ADHESIÓN Y SUBPOBLACIONES LINFOCITARIAS EN LESIONES DE PACIENTES CON ESTOMATITIS AFTOSA RECURRENTE

Resumen

Palabras clave: Estomatitis Aftosa Recurrente, moléculas de adhesión, inmunidad celular. 

Recurrent aphthous stomatitis (RAS) is the most common oral mucosal disease characterized by aphthous ulcerations in the oral mucosal. Actually the investigations have been directed to determine the etiology of the RAS with special attention to the cellular immune response. Aditionally, is very important to determine the rol of the adhesion molecules in this condition.
The purpose of this work was to determine the of the adhesion molecules expression, ICAm-1, VCAM-1, CD4 and CD8 cell count in patients with RAS. We evaluated 19 patients, 15 with RAS minor and 4 with major RAS. The control group included oral health tissue of subjects without RAS. We observed a higher level of CD8 cell count that suggest the implication of T cells and cellular immune response in the pathogenesis of this entity. The adhesion molecules expression was higher than in the control group. These results suggest that the adhesion molecules may play an important role in the cell interactions that we observed in this entity.

Key words: Recurrent aphthous stomatitis (RAS), oral lesions, adhesion molecules