Relationship between leptin and hypertension

Resumo

Leptin is secreted primarily by white adipose tissue and secondarily inoutrown fat. It participates as a satietysignal in the regulation of food intake. It promotes insulin resistance as well as nitric oxide –mediated vasodilation increasing the activity of the sympathetic system. Leptin stimulates insulin secretion out of adipose tissue too. This work was carried out to study how leptin affects the maintenance of hypertension and Diabetes mellitus type 2. Objective: to describe the interaction between leptin, diabetes and hypertension on healthy patients, the hypertensive diabetics type 2 as well as the relationship between leptin, non invasive hemodynamical variables and metabolic diseases. Methods: A crossed-comparative observational design research was done with 75 subjects who were selected and divided into three groups of 25 participants: Healthy, diabetics type 2 and hypertense. Patients were measured: anthropometric parameters, systolic blood pressure (SBP), diastolic blood pressure (DBP), and medial blood pressure (MBP). Biochemical variables as: insulin, glocose, HbA1c, HOMA-IR and leptin data were statistically analysed and described. Similarly, SBP, DBP and MAP were in the three groups (P>0.05). Conclusions: Leptin showed high levels in diabetic and hypertensive patients when compared with control group. The SBP, DBP.and MBP were altered in both diabetic and hypertense subjects resulting from the sympathetic system activation throughout leptin activity. In short, Diabetes type 2, which is an insulin resistance state, may be influenced by leptin levels as well as its relation with Diabetes Mellitus type 2 (DM2), and High blood pressure, (HBP).