High-sensitivity c-reactive protein epidemiological behavior in adult individuals from Maracaibo, Venezuela

Autores/as

  • Valmore Bermúdez
  • Mayela Cabrera
  • Laura Mendoza
  • Mervin Chávez
  • María Martínez
  • Joselyn Rojas
  • Alejandra Nava
  • Diego Fuenmayor
  • Vanessa Apruzzese
  • Juan Salazar
  • Yaqueline Torres
  • Tibisay Rincón
  • Luis Bello
  • Roberto Añez
  • Alexandra Toledo
  • Maricarmen Chacín
  • Marjorie Villalobos
  • Freddy Pachano
  • María Montiel
  • Miguel Angel Aguirre
  • Rafael París Marcano
  • Manuel Velasco

Palabras clave:

Cardiovascular disease, low-grade inflammation, risk factors, metabolic syndrome.

Resumen

Objectives: High-sensitivity C-Reactive Protein (hs-CRP) is one of the most applied inflammation markers; therefore, the main objective of this research is to evaluate its epidemiological behavior in adult subjects of the Maracaibo City, Venezuela. Materials and Methods: A total of 1,422 subjects, 704 women (49.5%) and 718 men (50.5%), were enrolled in the Maracaibo City Metabolic Syndrome Prevalence Study. The results were expressed as medians and inter-quartile ranges (p25-p75). Differences were determined through the Mann-Whitney U test and one-way ANOVA test with the Bonferroni adjustment. A multiple logistic regression model was designed for the analysis of the main factors associated with high serum hs-CRP levels. Results: Overall hs-CRP median was 0,.372 mg/L (0.126- 0.765 mg/L), 0,382 mg/L (0.122-0.829 mg/L) for women and 0.365 mg/L (0.133-0.712 mg/L) for men; p=0.616. An increasing pattern was observed in hs-CRP concentrations through age, BMI, waist circumference and HOMA2-IR categories. After adjusting for independent variables, a greater risk for elevated hs-CRP levels was observed with female gender, hypertriacylglyceridemia, obesity, diagnosis of metabolic syndrome and very large waist circumference values. Conclusions: Elevated hs-CRP levels are related to the metabolic syndrome but not with each of their separate components, being a greater waist circumference one of the more important risk factors, but only at values much higher than those proposed for our population. 

Biografía del autor/a

Valmore Bermúdez

MD, MPH, PhD

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela.

Mayela Cabrera

MD, MPH, PhD

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Laura Mendoza

MD, MPH, PhD

Functional Sciences Department. Faculty of Medicine. University of Zulia, Venezuela.

Mervin Chávez

Bsc

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

María Martínez

Bsc

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Joselyn Rojas

MD, MSc

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela.

Institute of Clinical Immunology. University of Los Andes. Mérida – Venezuela

Alejandra Nava

Bsc

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Diego Fuenmayor

Bsc

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Vanessa Apruzzese

Bsc

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Juan Salazar

Bsc

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

 

Yaqueline Torres

MD

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Tibisay Rincón

MD PhD

Functional Sciences Department. Faculty of Medicine. University of Zulia, Venezuela

Luis Bello

MD

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Roberto Añez

MD

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Alexandra Toledo

MD

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Maricarmen Chacín

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Marjorie Villalobos

MD

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Freddy Pachano

MD, PhD

Morphologic Sciences Department and Pediatric Surgery Department. Faculty of Medicine. University of Zulia, Venezuela

María Montiel

MgSc

Institute of Work Medicine. Faculty of Medicine. University of Zulia, Venezuela.

Miguel Angel Aguirre

MSc

Endocrine-Metabolic Research “Dr. Félix Gómez”. Faculty of Medicine. University of Zulia, Venezuela

Endocrinology Unit, I.A.H.U.L.A, Mérida – Venezuela

Rafael París Marcano

MD, MPH, PhD

Public Health Department. Faculty of Medicine. University of Zulia, Venezuela

Manuel Velasco

MD, PhD

Unidad de Farmacología Clínica. Escuela de Medicina Vargas. Universidad Central de Venezuela. Caracas, Venezuela

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