Clinical and Biochemical diagnosis of patients with febrile neutropenia attended Babylon Cancer Treatment center

Resumen

Background: Febrile neutropenia define as an oral fever of more than 38.3°C or ≥ 38.0°C sustained for more than one hour, with absolute neutrophil count (ANC) should be <500/μL. FN associated with high rate of disease indisposition, mortality, affect chemotherapy price and doses, and leading to chemotherapy course interruptions, as well as affects the chemotherapy potency. Aim of study: This study was aimed to estimate the patients that have cancer and newly diagnosed with febrile neutropenia Patients and methods: A retrospective study that included one hundred and fifty patients already diagnosed with cancer who attended the outpatient clinic of Babylon Cancer Treatment Center, from 1^st of January 2020 to 1^st of January 2021. Results: From a total of 150 patients, age of patients ranged from 20-85 years, with mean age of 62.3±10.17 years, 63(42%) were males and 87(58%) were females. Breast cancer form 40%, as the most common solid cancers presented with febrile neutropenia, while head and neck cancer form 2%. We found 20% blood culture positive, and E. coli most bacterial isolated (40%), while 8.66% was positive urine culture and E. coli was form 84.6% also most commonly urine bacterial isolated, and only 2.66% sputum culture was positive and S. pneumonia is most common bacterial isolated (50%). 73.34% of patients presented with fever without localizing symptoms, while 12.66% of patients presented with respiratory system related symptoms. We found day 8^th after last cycle of chemotherapy was the most day of starting fever (28.66%). Conclusion: FN is a leading cause of cancer related death, early management is required to decrease rate of mortality.