Platelet indices as predictors of fetal growth restriction in Pre-eclamptic Women

Resumen

Abstract: Background: Preeclampsia PE is one of the mysterious ailments implicating maternal and fetal well-being; fetal growth restriction is a well-known complication. This study links between platelet indices observed in PE deemed mothers and fetal growth restriction in involved fetuses in 34 weeks of pregnancy. Methodology: a cross-sectional study enrolled 33 patients randomly collected over 1 year, all with severe PE diagnoses based on the NICE 2019 guideline. Informed consent, history, and physical examination, including mean blood pressure, were gathered. For each participant, blood samples were obtained for platelet indices, including a platelet distribution width and mean platelet volume. An ultrasound and Doppler measurements evaluating the birth weight percentile and amniotic fluid index, Dopplers pulsatility, and resistance index [PI & RI]. Result: analysis showed a mean maternal BP of 93.3±9.8 ml/hg, mean platelet volume of 9.4±0.29 μm3, platelet distribution width of 17.7±1.1 percent. The ultrasound showed an amniotic fluid index of 6.34±264 cm and a mean fetal weight centile of 30.81±14.4 kg. As for Dopplers indices; the resistance index & pulsatility index of umbilical arteries UA showed 3.7288±15.9253 and 2.5216±0.3689 respectively. A correlation was found between the platelet distribution width and the pulsatility index by the coefficient of mallows. A platelet distribution width higher than 75% associate odds ratio of 16, and P-value=0.0131 for prediction of growth-retarded baby. In an amniotic fluid volume <5 cm, an odds ratio of 9 and a P-value =0.033 for prediction of growth-retarded baby. Conclusion: platelets indices PWD may serve as a good predictor of growth restriction in pre-eclamptic mothers along with amniotic fluid index & PI.