Correlation of IDA severity with endoscopic, histopathological and serological findings in CD patients at AL-Anbar district, [west of Iraq]: A Comparative cross-sectional study

Resumen

Abstract: Celiac disease (CD) is an autoimmune disorder described as a chronic inflammatory reaction due to gluten ingestion, which induces a particular degree of villous atrophy & possible -nutrient -malabsorption. Multi etiological factor of Anemia in CD patients; at the same time, iron deficiency anemia (IDA) may also be the most frequently recorded characteristic in children and adults with CD perhaps it is a unique finding existing. No previous study regarding the correlation of endoscopic, histopathological, and serological features of CD patients with IDA at Al-Anbar province. To find the correlation between the severity of IDA with endoscopic, histopathological, and serological features of CD patients. Hospital-based comparatives cross-sectional study was conducted in the Gastroenterology Clinic of AL-Ramadi teaching hospital attached to Anbar Medical College, Ramadi, Iraq from August 2017 through June. 2020. A total of 108 consecutive new CD cases with iron-deficiency anemia, 70 of them were females, and 38 were males. CBC, blood films, ferritin level, endoscopic findings had been registered for all CD patients. In every CD case, gastro¬intestinal biopsies in addition to lgA (AntitTG levels) had been recorded. Histo¬pathology outcomes had been separated through the use of "taxonomy of modified¬ Marsh". A proper suitable statistical analysis had observed results.  A total of 108 CD patients with iron deficiency anemia the mean age was 28.86 with a range from 15 -66 years; the female was 64.8% and male 35.2%. There was a weak negative significant correlation Corr. Coef (r) (R=-0.003, p=0.000& R=-0.0180.161, p=0.000) amongst endoscopic and histopathological findings with IDA severity (HB gr%) respectively of CD patients using spearman's correlation coefficients (r). Negatively non-significant correlation of Anti- tTG level with IDA severity of CD (HB gr%) patients as detected through the use of Pearson’s correlation (R=-149; P values 0.123). A weak negative significant correlation was found between the severity of IDA with endoscopic, histopathological finding, and but there was a negatively non-significant correlation between anti- tTG IgA level and IDA severity in CD.