Investigation of drug -drug interactions status, in University-Based Pharmacies, in Lorestan, IRAN

Resumen

rug drug interaction, is an importantcause for disturbing of medical managementof a disease that usually is preventive,must be continuously investigated for detection ofcauses. Due to little data about it in recently years in thisarea, study was done, to investigate of quantity of interactions,and some related factors. In this cross sectionalstudy, all prescriptions data from April to October 2016were collected. Variable data included: type and nameof drugs- the number of drugs in each prescription andcharacteristics of interactions. We used software of druginteraction fact and lexicomp on desk top DI and textbook‘Drug Interaction Facts’ .Statistical analysis done by t testand use of SPSS 19. Finally, 41096 prescriptions were collected.From these data 56% were male. 3043 of subjectshad DDI (7.4%). most interaction was in 5th degree andmajority of interactions were mild. DDI between ammoniumchloride and pseudoephedrine –antihypertensivedrugs and others-omeprazole and chlordiazepoxide hadthe most frequency, respectively. About interaction show,53% was delay and 43% was rapid. The mean quantity ofdrugs was less than four type drugs in each prescription.We conclude that, general and even OTC drug had greatDDI that must be notice to these drugs in prescriptions.There was no correlation between gender or specialtyof physician and frequency of DDI (p=0.08). Quantityof drugs in each prescription, correlate with rate of DDI(p=.003). Attendance a pharmacist in treatment team ofpatients could be helpful, for decrease the rate of DDI. Inall centers, continuous and more research for detectingDDI is necessary.