Evaluation of cream composed of urea and natural extracts of R. Officinalis, C. Lechleri and A. Vera for humidifying the skin in diabetic foot

Resumen

Topical medications using urea has been useful to reestablish skin physiological conditions. In this prospective, mono-centric clinical trial we apply a formulation based on urea and natural extract of R. officinalis, C.lechlery and A. vera to 40 diabetic patients. The skin clinical response was evaluated after and before the medication. Optimal results were found in patients, the assayed formulation reduced the pathological symptoms characterizing diabetic foot skin. In particular hyperkeratosis, dryness and scaling. Formulation was shown it ability to significant (p<0.05) improve the bio-physic characteristics of the diabetic skin (pH and moisture). In addition it was significant (p<0.05) improved the barrier function of the skin with the consequent protective effect. The formulation showed it excellent moisturizing, tolerability, fastaction, and cosmetic properties.