Saber UCV
Repositorio Institucional
Repositorio Institucional
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https://saber.ucv.ve/handle/10872/4634
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| Title: | Sodium-Calcium Exchanger Modulates the L-Glutamate Ca i 2+ Signalling in Type-1 Cerebellar Astrocytes |
| Authors: | Rojas, H Colina, C Ramos, M Benaím, Gustavo Jaffe, E Caputo, C Di Polo, R |
| Keywords: | Na + /Ca 2+ exchange CICR Glutamate Glutamate transporter |
| Issue Date: | 2013 |
| Publisher: | Experimental Medicine and Biology |
| Citation: | Avances en Medicina Experimental y Biología 961 |
| Abstract: | We have previously demonstrated that rat type-1 cerebellar astrocytes express a very active Na + /Ca 2+ exchanger which accounts for most of the total plasma membrane Ca 2+ fl uxes and for the clearance of Ca i 2+ induced by physiological agonist. In this chapter, we have explored the mechanism by which the reverse Na + /Ca 2+ exchange is involved in agonistinduced Ca 2+ signalling in rat cerebellar astrocytes. Laser-scanning confocal microscopy experiments using immuno fl uorescence labelling of Na + /Ca 2+ exchanger and RyRs demonstrated that they are highly co-localized. The most important fi nding presented in this chapter is that L -glutamate activates the reverse mode of the Na + /Ca 2+ exchange by inducing a Na + entry through the electrogenic Na + -glutamate co-transporter and not through the ionophoric L -glutamate receptors as con fi rmed by pharmacological experiments with speci fi c blockers of ionophoric L -glutamate receptors, electrogenic glutamate transporters and the Na/Ca exchange. |
| URI: | http://hdl.handle.net/10872/4634 |
| ISSN: | DOI 10.1007/978-1-4614-4756-6_22, |
| Appears in Collections: | Artículos Publicados |
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