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|Título : ||Decreased T-cell proliferative response to common environmental antigens could be an indicator of early human immunodeficiency virus-mediated lymphocyte lesions.|
|Autor : ||Tassinari, Paolo|
Bianco Colmenares, Nicolás E.
Echezuría de Pérez, Gloria
|Palabras clave : ||HIV|
|Fecha de publicación : ||Jul-1995|
|Editorial : ||Clin Diagn Lab Immunol|
|Citación : ||Clin Diagn Lab Immunol|
|Resumen : ||To evaluate CD4+/CD29+ cells and their responses to different antigens in polar
stages of human immunodeficiency virus (HIV) infection, we studied 26
HIV-seropositive carriers (SPCs) and 15 patients with AIDS simultaneously with 20
healthy volunteers (HVs) and 10 seronegative homosexual and bisexual men (SNH).
CD3, CD4, CD29, and CD45RA phenotypes were analyzed by two-color flow cytometry.
Significant depletion of CD4+ T cells and both memory (CD4+/CD29+) and naive
(CD4+/CD45RA+) T-cell subsets was found among SPCs and AIDS patients compared
with the numbers of such cells in the HV and SNH groups. Responses to optimal
doses of Candida albicans, streptokinase, and tetanus toxoid were explored in
peripheral blood mononuclear cells and CD4(+)- and CD4+/CD29(+)-enriched cell
populations. In SPCs, the response to C. albicans in peripheral blood mononuclear
cells showed a statistically significant diminution compared with the response of
HVs (15,308 versus 35,951 cpm). In addition, a significantly reduced response to
streptokinase was evident only when cell preparations were CD4+/CD29+ enriched
(3,048 versus 10,367 cpm). Furthermore, the SPC group comprised seven responders
to at least one antigen and seven nonresponders to any of the selected specific
antigens. Absence of a response in these latter patients was independent of the
absolute counts of memory and naive T-cell populations. The response to tetanus
toxoid, although diminished in SPCs, was not significantly different from that in
controls. Our results suggest that defective responses to common environmental
antigens, unrelated to the absolute number of CD4+/CD29+ cells, is probably an
early indicator of an HIV-induced lymphocyte lesion.
PMID: 7583914 [PubMed - indexed for MEDLINE]|
|URI : ||http://saber.ucv.ve/jspui/handle/123456789/6977|
|Aparece en las colecciones: ||Artículos Publicados|
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