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|Título : ||Hypoglycemic Activity of Extracts and Compounds from the Leaves of Hintonia standleyana and H. latiflora: Potential Alternatives to the Use of the Stem Bark of These Species|
|Autor : ||cristians, sol|
|Palabras clave : ||H. latiﬂora|
|Fecha de publicación : ||29-Apr-2014|
|Resumen : ||The CH2Cl2-MeOH (1:1) extract of the leaves of Hintonia standleyana and H. latiﬂora caused signiﬁcant decrease in
blood glucose levels in both normal and streptozotozin (STZ)-induced diabetic rats when compared with vehicle-treated
groups (p < 0.05). These extracts were not toxic to mice according to the Lorke criteria. From the hypoglycemic
extract of H. standleyana, two new 4-phenylcoumarins, namely, 6′′-O-acetyl-5-O- -D-galactopyranosyl-7,4′-dihydroxy-
4-phenylcoumarin (1) and 6′′-O-acetyl-5-O- -D-galactopyranosyl-7,3′,4′-trihydroxy-4-phenylcoumarin (2), were obtained.
The analogous extract of H. latiﬂora yielded the new 5-O-[ -D-xylopyranosyl-(1f6)- -D-glucopyranosyl]-7,4′-dimethoxy-
4-phenylcoumarin (3) along with several known compounds, including ursolic acid and desoxycordifolinic acid.
Phenylcoumarins 1 and 2 showed hypoglycemic activity. HPLC proﬁles of the leaf extracts of both plants revealed the
presence of known hypoglycemic phenylcoumarins as well as chlorogenic acid. The overall results have indicated that
the leaves of H. standleyana and H. latiﬂora possess similar antidiabetic potential to their stem bark. Therefore, the
leaves from these species could represent an alternative to the use of their stem bark, which, in turn, would contribute
to the conservation of these Mexican medicinal plants|
|URI : ||http://saber.ucv.ve/jspui/handle/123456789/6162|
|Aparece en las colecciones: ||Artículos Publicados|
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