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Título : Antibody Responses and Resistance against Ascaris lumbricoides Infection among Venezuelan Rural Children: The Influence of Ethnicity
Autor : Hagel, Isabel
Cabrera, Maira
Buvat, Erika
Gutierrez, Loana
Santaella, Carlos
Borges, Rafael
Infante, Benito
Salas, Carolina
Barrios, Yelitza
Palabras clave : IgE IgG4 Amerindians
Fecha de publicación : 3-May-2008
Editorial : Journal Tropical Pediatrics
Citación : J Trop pediatr
Citación : vol 54;5
Resumen : We studied the production of anti parasite antibodies and the resistance against A. lumbricoides infection among the school population of three different Venezuelan ethnic groups: Warao Amerindians, Afro- Americans and white ‘Creole’ descendents. The prevalence and intensity of A. lumbricoides were determined before and after 1 year of anthelminthic treatment. Parasitic loads were associated to pre-treatment serum levels of anti A. lumbricoides IgE and IgG4 antibodies. The intensity of the infection and the proportion of re-infected children were significantly lower (p<0.0001) among the Warao Amerindians, exhibiting higher levels of IgE (p<0.0001) and lower levels of IgG4 (p<0.0001) compared to their non-Amerindian counterparts. IgE levels correlated inversely with the proportion of re-infected children, whereas the levels of IgG4 were positively associated. These results suggest that ethnicity may influence the balance of IgE/IgG4 levels, modulating the intensity of A. lumbricoides and the resistance to the infection.
Descripción : En este trabajo se demuestra que diferencias en la produccion de anticuerpos especificos frente a Ascaris lumbricoides entre la poblacion infantil de diferentes grupos etnicos de venezuela difieren se relacionan con diferencias en la resistencia frente a la infeccion.
URI : http://saber.ucv.ve/jspui/handle/123456789/5634
ISSN : 0142-6338
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