SABER UCV >
1) Investigación >
Artículos Publicados >
Por favor, use este identificador para citar o enlazar este ítem:
|Título : ||Infection by Ascaris lumbricoides and bronchial hyper reactivity: An outstanding association in Venezuelan school children from endemic areas|
|Autor : ||Hagel, Isabel|
Di Prisco, María Crístina
|Palabras clave : ||Ascaris infection; Bronchial hyper reactivity; IgE antibodies; CD23 receptor|
|Fecha de publicación : ||7-Jul-2007|
|Editorial : ||Acta Tropica|
|Citación : ||Acta Tropica|
|Citación : ||vol 103;3|
|Resumen : ||Asthma and other respiratory diseases have increased in the last years among Venezuelan children from helminthic endemic areas
where the infection by Ascaris lumbricoides has been associated to bronchial airway inflammation in parasitized individuals. The
aim of this work was to investigate the possible associations between the development of bronchial hyper reactivity and the immune
response against A. lumbricoides in urban and rural children.We evaluated 470 school children from rural and urban communities.
Pulmonary function tests were performed and ≥20% PC20 changes were considered as a positive diagnostic of bronchial hyper
reactivity. The prevalence and intensity of A. lumbricoides infectionwas determined by faecal examination. Specific serum IgE levels
using a modified ELISA and skin prick tests against A. lumbricoides and the common allergen Dermatophagoides pteronyssinus
were done. The number of circulating lymphocyte sub populations was determined by flow cytometry analysis. In rural children,
bronchial hyper reactivity was associated with increased specific levels of anti-A. lumbricoides IgE (p < 0.0001) and skin test
positivity for A. lumbricoides (p < 0.0001). The percentage of FEV1 predictive values correlated inversely (p < 0.0001) with anti-A.
lumbricoides IgE levels. Elevated numbers of circulating CD3+CD4+ and CD20+CD23+ cells were found in rural children with
bronchial hyper reactivity compared to their asymptomatic counterparts. They correlated positively with anti-A. lumbricoides IgE
levels (p < 0.005 and < 0.0001, respectively). In contrast, in urban children, bronchial hyper reactivity was associated with elevated
anti-D. pteronyssinus IgE levels (p = 0. 0089), skin hyper reactivity towards this aero allergen (p = 0.003) and to an increase in the
number of CD3+CD8+ (p < 0.0001). Our results suggest that the IgE response against A. lumbricoides infection may be involved in
the development of bronchial hyper reactivity among rural children from endemic areas and also that improved hygienic conditions
in the urban environment is associated with increased responses to airborne allergens.
© 2007 Elsevier B.V. All rights reserved.
Keywords: Ascaris infection; Bronchial hyper reactivity; IgE antibodies; CD23 receptor|
|Descripción : ||Este trabajo demuestra la relacion entre la presencia de antigenos de Ascaris lumbricoides con la hiperreactividad bronquial presente en la poblacion infantil rural Venezolana.|
|URI : ||http://saber.ucv.ve/jspui/handle/123456789/5632|
|ISSN : ||0001-706X|
|Aparece en las colecciones: ||Artículos Publicados|
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.