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Título : Do intestinal parasites enhance food allergy and atopic dermatitis?: A study in Warao Amerindian children
Autor : Hagel, Isabel
Puccio, Franca
Lopez, Elianska
Lugo, Dennis
Cabrera, Maira
Di Prisco, María Crístina
Palabras clave : atopic dermatitis; food allergy; Giardia duodenalis; IgE; IL13; IL-6; TNF-a
Fecha de publicación : 6-Jan-2014
Editorial : Pediatric Allergy and Immunology
Citación : pediatr Allergy Immunol
Citación : DOI:10.1111/pai.12190;00
Resumen : Background: We evaluated the influence of intestinal parasitic infection on food sensitization associated to the severity of Atopic Dermatitis (AD) in a group of Warao Amerindian pre- school children. Methods: Feces examinations were performed in fresh stool specimens. Diagnosis of AD was done according to Hannifin and Rajka criteria and SCORAD index. Skin prick tests (SPT) were performed using extracts of cow’s milk (CM), hen’s egg (HE), Dermatophagoides pteronyssinus and Dermatophagoides farinae . Serum CM and HE-IgE levels (ELISA) were measured. Quantikine (R&D systems) assays were used for the determination of IL-13, TNF-a IL-6, and sCD23 in supernatants of CM- and HE- whole blood stimulated samples. Results: Atopic Dermatitis was reported in 23% of the children. It was significantly (p < 0.0001) associated toward both CM and HE- SPT positivity (p < 0.001). Giardia duodenalis infection (37%) was associated to the presence of AD (p = 0.005) and to a significant increase in the levels of CM stimulated TNF-a (p ¼ 0:006), IL-13 (p = 0.01), sCD23 (p = 0.001), CM-IgE (p = 0.012) and CM-SPT (p < 0.0001). Similarly, G. duodenalis infection was particularly associated with the increase on the levels of HE-stimulated TNF-a (p = 0.001), sCD23 (p = 0.001), HE-IgE levels (p = 0.002) and HE-SPT (p = 0.001). Conclusion: Gut inflammation caused by G. duodenalis may enhance food allergic reactivity contributing to the manifestation of AD in these children. However, other environmental factors (not considered in this work) as well as an atopic background among the Warao population would also contribute to the presence of AD.
Descripción : Este trabajo establece la influencia de la reactividad alergica frente a alimentos como leche y huevo asi como de la presencia de factores inmunologicos pro-inflamatorios tipo TH2 sobre la elevada prevalencia de dermatitis atopica encontrada en a poblacion infantil de la etnia Warao
URI : http://saber.ucv.ve/jspui/handle/123456789/5630
ISSN : 1399-3038
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