SABER UCV >
1) Investigación >
Artículos Publicados >

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/123456789/5432

Título : Tropical medicine rounds. Immunopathologic study of erythema dyschromicum perstans (ashy dermatosis)
Autor : Vásquez-Ochoa, Luz A.
Isaza-Guzmán, Diana M.
Orozco-Mora, Beatriz
Restrepo-Molina, Rodrigo
Trujillo-Perez, Judith
Tapia, Félix J.
Palabras clave : Immunopathology
erythema
dermatosis
pigmentary disease
dermal lymphocytic
histopathology
Fecha de publicación : 2006
Editorial : International Journal of Dermatology
Resumen : Erythema dyschromicum perstans (EDP) is a pigmentary disease of unknown etiology in which damage to basal cells is thought to be mediated by adhesion molecules. The aim of this study was to characterize the histopathology and immunopathology of EDP. Forty-three patients from Medellín, Colombia, with the diagnosis of EDP were evaluated. Skin biopsy specimens were obtained for histopathology and immunohistochemistry, using monoclonal antibodies directed against the following markers: CD4, CD8, CD56, CD1a, CD68, CLA, HLA–DR, ICAM-1 and LFA-1α. A dermal lymphocytic infiltrate was observed in all cases, with a perivascular location in 86%. Other histologic features included melanophages in all specimens, vacuolization of the basement membrane zone (BMZ) 58% and exocytosis of lymphocytes (53.5%). The mean number of total leukocytes was 1510 cells mm −2 of tissue. There was a predominance of CD8+T lymphocytes in the dermis and HLA–DR+, ICAM-1+ keratinocytes in the epidermis. Exocytosis of cutaneous lymphocyte antigen (CLA) + cells was observed in areas of BMZ damage, suggesting that response to antigenic stimulation may play a role in the development of EDP.
URI : http://saber.ucv.ve/jspui/handle/123456789/5432
ISSN : 1365-4632
Aparece en las colecciones: Artículos Publicados

Ficheros en este ítem:

Fichero Descripción Tamaño Formato
Vásquez-Ochoa, Isaza ... Tapia 2006.pdf152.25 kBAdobe PDFVisualizar/Abrir

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2008 MIT and Hewlett-Packard - Comentarios