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Título : Experimental ophitoxemia produced by the opisthoglyphous lora snake ( Philodryas olfersii ) venom
Autor : Rodríguez-Acosta, Alexis
Lemoine, Karel
Navarrete, Luis
Girón, María E.
Aguilar, Irma
Palabras clave : Colubridae
Haemorrhage
Neurotoxic
Philodryas olfersii
Fecha de publicación : 27-Nov-2013
Citación : Revista da Sociedade Brasileira de Medicina Tropical;39(2):193-197, 2006
Resumen : Several colubrid snakes produce venomous oral secretions. In this work, the venom collected from Venezuelan opisthoglyphous (rear-fanged) Philodryas olfersii snake was studied. Different proteins were present in its venom and they were characterized by 20% SDS-PAGE protein electrophoresis. The secretion exhibited proteolytic (gelatinase) activity, which was partially purified on a chromatography ionic exchange mono Q2 column. Additionally, the haemorrhagic activity of Philodryas olfersii venom on chicken embryos, mouse skin and peritoneum was demonstrated. Neurotoxic symptoms were demonstrated in mice inoculated with Philodryas olfersii venom. In conclusion, Philodryas olfersii venom showed proteolytic, haemorrhagic, and neurotoxic activities, thus increasing the interest in the high toxic action of Philodryas venom.
URI : http://saber.ucv.ve/jspui/handle/123456789/5114
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