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Título : Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats
Autor : Torrico, Fatima
Cepeda, Mariana
Guerrero, Geraldine
Melendez, Fidel
Blanco, Zuleima
Canelón, Dilsia
Diaz, beth
Compagnone, Reinaldo
Suárez, Alírica
Palabras clave : Croton cuneatus, blood glucose
Fecha de publicación : 15-Nov-2013
Citación : Brazilian Journal of Pharmacognosy;17(2) 2007 pp 166-169
Resumen : Aqueous extract of stem barks of Croton cuneatus Klots (Euphorbiaceae) was investigated for hypoglycaemic activity in streptozotocins (STZ)-induced diabetic rats. Increasing doses of aqueous extract (6.5, 13, 26 and 52 mg/KG i.p.) were separately administeres to groups of fasted normal and diabetic rats. Plasma glucose concentration, cholesterol and changes in body weight were evaluated. The chronic intraperitoneal (i.P.) administration of the extract for 22 days was found to induce significant reduction in blood glucose level. A comparison was made between tha action of the aqueous extract of C. cuneatus and the reference standard drug glibenclamide. The results of this experimental animal study indicate that this plant has an antidiabetic activity in hiperglycaemic rats models
URI : http://saber.ucv.ve/jspui/handle/123456789/4907
ISSN : 0102-695X
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