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Título : Scorpions from the primeval subgenus Archaeotityus produce putative homologs of Tityus serrulatus toxins active on voltage-gated sodium channels
Autor : Borges, Adolfo
Jowers, Michael J.
Bónoli, Stéfano
De Sousa, Leonardo
Palabras clave : Tityus clathratus
Tityus serrulatus
Venezuela
Scorpion toxins
Fecha de publicación : 30-Nov-2012
Editorial : Journal of Venomous Animals and Toxins including Tropical Diseases
Citación : J. Ven. Animals Tox. incl. Trop. Dis. 18 (2012), 432-440
Citación : 18;4
Resumen : It has been proposed that the subgenus Archaeotityus comprises the most ancient species group within the medically important scorpion genus Tityus. cDNA encoding sodium-channel active toxins from the type species of this subgenus, Tityus clathratus (central Venezuela), have been isolated and sequenced. Two cDNAs were retrieved that encoded 61 amino acid-long putative neurotoxins named Tcl1 and Tcl2. Sequence identity was highest (87%) when both were compared with β-toxin Ts1 from the Brazilian scorpion Tityus serrulatus and its homologs from T. bahiensis, T. stigmurus, and T. costatus. A Bayesian analysis indicated statistical support for the grouping of T. clathratus Tcl1 and Tcl2 with Brazilian gamma-like β-toxins, reinforcing previous phylogenetic studies which suggested an evolutionary relationship between the subgenus Archaeotityus and scorpion species inhabiting southeast South America belonging to the subgenus Tityus.
URI : http://saber.ucv.ve/jspui/handle/123456789/4900
ISSN : 1678-9199
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