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|Título : ||Variations in the serum levels of soluble CD23, nitric oxide and IgE across the spectrum of American cutaneous leishmaniasis|
|Autor : ||Cabrera, Maira|
|Palabras clave : ||cutaneous leishmaniasis|
|Fecha de publicación : ||Oct-2003|
|Editorial : ||Elsevier|
|Citación : ||Acta Tropica 88 (2003) 145–151|
|Citación : ||88;|
|Resumen : ||Serum IgE levels and the expression of low affinity receptor for IgE (FcεRII/CD23) are increased in cutaneous leishmaniasis.
The ligation of CD23 receptor by IgE–anti-IgE immune complexes results in nitric oxide (NO) production, which is a critical leishmanicidal factor. Human monocytes/macrophages express FcεRII/CD23 after activation with IFN- and IL-4. In the present study,we assessed the relationship between NO, total and Leishmania-specific IgE and soluble CD23 across the clinical spectrum of American cutaneous leishmaniasis (ACL). Sixty-nine ACL patients and 22 endemic controls were studied. NO concentration was estimated using the Greiss method. Soluble CD23, total IgE and anti-Leishmania IgE levels were measured using ELISA.
Soluble CD23 was increased in the four patient groups (0.001 < P < 0.05) compared by the Mann–Whitney test to healthy
subjects, particularly in mucocutaneous leishmaniasis (MCL) and diffuse cutaneous leishmaniasis (DCL) patients. Total IgE
levels were higher inACL patients (P < 0.0001). Anti-Leishmania IgE showed a similar tendency, whereMCLand DCL patients
had greater levels. All patients groups, except intermediate or chronic cutaneous leishmaniasis (ICL) patients, showed elevated
levels of NO2−/NO3 − compared to healthy individuals (0.001 < P < 0.01). Interestingly, ICL patients did not produce significant levels of NO2−/NO3−. ACL patients showed a significant positive correlation between soluble CD23 and anti-Leishmania IgE.
DCL patients showed a positive correlation between both parameters.
Overall results suggest that sCD23, IgE and NO may play different roles across the ACL spectrum.|
|URI : ||http://saber.ucv.ve/jspui/handle/123456789/4894|
|ISSN : ||0001-706X|
|Aparece en las colecciones: ||Artículos Publicados|
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