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|Título : ||Hemoglobin variants, hematological parameters and -globin gene cluster haplotypes in an isolated Amerindian group from the Orinoco River Delta|
|Autor : ||Arends, Anabel|
Bravo Urquiola, Martha
Arends de Ojeda, Tibisay
|Palabras clave : ||Haplotypes|
|Fecha de publicación : ||5-Dec-2008|
|Editorial : ||Annals of Human Biology|
|Citación : ||3|
|Resumen : ||Background: Several previous studies reported that the Venezuelan Warao Indians presented unusual
Aim: The present study checked previous reports of a high frequency of hereditary persistence of fetal
hemoglobin (HPFH) and examined other hematological traits.
Subjects and methods: Standard hematology, electrophoresis on cellulose acetate, fetal hemoglobin alkali
denaturation, -globin chain, DNA amplification and sequencing, and denaturing gradient gel
electrophoresis determinations were performed in 269 individuals living in two localities of the
Orinoco River Delta.
Results: Two s genes, in apparently non-related individuals, were found. HPFH, detected in this same
population of Warao Indians 25 years ago, was present in heterozygous form in five individuals from a
large kindred, with hemoglobin F levels ranging from 3.7% to 8%, and with a pancellular distribution.
The HPFH mutation was of the deletional type. -globin gene haplotypes were determined by direct
counting (through family studies) in 150 chromosomes; 26% of the 150 examined cluster presented
haplotype 2, 22% haplotype 6, and 13% a new, Warao haplotype. Haplotype 3, of probable African
origin, was also found with a frequency of 5%.
Conclusions: The presence of the HPFH mutation was confirmed, and the new -globin gene haplotype
together with the presence of other rare variants indicates that the Warao are very distinctive in relation
to other Native Americans. Evidence was also found of a slight admixture from Africa-derived subjects
(Layrisse et al. 1988).|
|URI : ||http://saber.ucv.ve/jspui/handle/123456789/4708|
|ISSN : ||0301–4460|
|Aparece en las colecciones: ||Artículos Publicados|
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