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Título : Sodium-Calcium Exchanger Modulates the L-Glutamate Ca i 2+ Signalling in Type-1 Cerebellar Astrocytes
Autor : Rojas, H
Colina, C
Ramos, M
Benaím, Gustavo
Jaffe, E
Caputo, C
Di Polo, R
Palabras clave : Na + /Ca 2+ exchange
CICR
Glutamate
Glutamate transporter
Fecha de publicación : 2013
Editorial : Experimental Medicine and Biology
Citación : Avances en Medicina Experimental y Biología 961
Resumen : We have previously demonstrated that rat type-1 cerebellar astrocytes express a very active Na + /Ca 2+ exchanger which accounts for most of the total plasma membrane Ca 2+ fl uxes and for the clearance of Ca i 2+ induced by physiological agonist. In this chapter, we have explored the mechanism by which the reverse Na + /Ca 2+ exchange is involved in agonistinduced Ca 2+ signalling in rat cerebellar astrocytes. Laser-scanning confocal microscopy experiments using immuno fl uorescence labelling of Na + /Ca 2+ exchanger and RyRs demonstrated that they are highly co-localized. The most important fi nding presented in this chapter is that L -glutamate activates the reverse mode of the Na + /Ca 2+ exchange by inducing a Na + entry through the electrogenic Na + -glutamate co-transporter and not through the ionophoric L -glutamate receptors as con fi rmed by pharmacological experiments with speci fi c blockers of ionophoric L -glutamate receptors, electrogenic glutamate transporters and the Na/Ca exchange.
URI : http://saber.ucv.ve/jspui/handle/123456789/4634
ISSN : DOI 10.1007/978-1-4614-4756-6_22,
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