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Título : Quantitative Distribution of Angiotensin II Binding Sites in Rat Brain by Autoradiography
Autor : Saavedra, Juan M.
Israel, Anita
Plunkett, Laura M.
KURIHARA, MASAKI
SHIGEMATSU, KAZUTO
Correa, Fernando
Palabras clave : Quantilalivc autorad¡ography
Computerized microdensitometry
lmage analysis
Circumventricular organs
Hypothalamic nuclei
Nuc¡cus supmchiasmatis
Nucleus paravcntricularis
Eminenlia mediana
Brainstem nuclei
Nuclcus tractus solitarius
Angiotensin ll reccptors
Fecha de publicación : 26-Nov-1985
Editorial : Peptides
Citación : Vol. 7.;
Resumen : Angiotensin ll binding sites were localized and quantified in individual brain nuclci frorn single rats by incubation of ussue sections with I nM ra¡.lSarrl-angiotcnsin II. frHl-Ultrofilm autoradiography. computerized microdensitometry and comparison with rr¡-standards. High angiotensin II binding was present in the circumvcntricular organs (organon vasculosum laminac tcrminal¡s. orga¡on subfornicalis and arca postrema). in sclccted hypolhalamie nuclei (nuclei suprachiasmatis pcrivcnlricularis and peRvcntricularis) and in rhe nuclcus tractus olfactorii lateralis, thc nucleus preopticus medianus. the dorsal molor nucleus ofthe yagus and the nucleus tractus solitarii. High aflinity (Ka from 0.1 to l.5x l0e M-r)angliolensin ll bindirg sites were demonitrated in the organon subfomrcalis, the nuclcus tractus solitarii and the area postrema after incubation of consecutivc sections from single ral brains with ¡r5l-fSartl-angiotcnsin II in concentrations from 100 pM to 5 nM. These results demonstate and chamcterize brain binding sites for angiotensin ll of variable high añinily binding both inside and outsidc the blood-brain barrier.
URI : http://saber.ucv.ve/123456789/181
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