SABER UCV >
1) Investigación >
Artículos Publicados >

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/123456789/1737

Título : ABC Transporter Blockers and Reversal of Drug Resistance in Microorganisms.
Autor : Ponte-Sucre, Alicia
Padron-Nieves, Maritza
Diaz, Emilia
Palabras clave : ABC transporters
Drug resistance reversal
Fecha de publicación : 30-Aug-2012
Citación : In ABC transporters in microorganisms: Research, Innovation and Value as Targets against Drug Resistance;177-195
Resumen : One of the major causes of drug resistance and chemotherapeutic failure in both cancer and anti-infective therapies is the decrease of effective drug concentrations at their target place, due to the increased action of ATP-binding cassette (ABC) transporters. ABC transporters encompass membrane proteins that couple the energy derived from ATP hydrolysis to the translocation of solutes across biological membranes. Their functions include ancient and conserved mechanisms related to physiological mechanisms in prokaryotes and eukaryotes, emphasizing the biological relevance of ABC transporters. Since ABC transporter blockers can be used in combination with current drugs to increase their effective intracellular concentration, the possible impact of ABC transporter inhibitors is of great clinical interest. Special concern exists since scarce ABC transporter blockers that may be useful to increase the efficacy of current drugs have entered clinical trials and are available to be used in therapeutic regimes. Herein we review the progress made in recent years in the identification, design, availability and applicability of compounds that may work as ABC transporter blockers, as well as the roles of these compounds not only by directly blocking ABC transporters but also in the pharmacokinetics and pharmacodynamics of therapeutic drugs used against infectious diseases. These data may be helpful in the design of strategies to circumvent drug resistance in microorganisms including parasites in clinical circumstances.
URI : http://saber.ucv.ve/123456789/1737
ISBN : 978-1-904455-49-3
Aparece en las colecciones: Artículos Publicados

Ficheros en este ítem:

Fichero Descripción Tamaño Formato
Ponte-Sucre-Padron-Nieves-Diaz.pdfArticulo principal295.75 kBAdobe PDFVisualizar/Abrir
Ponte-Sucre Fig. 1.TIFFigura 175.26 kBTIFFVisualizar/Abrir
Ponte-Sucre Fig. 2.TIFFigura 280.97 kBTIFFVisualizar/Abrir
Ponte-Sucre Fig. 3.TIFFigura 388.25 kBTIFFVisualizar/Abrir
Ponte-Sucre Fig. 4.TIFFigura 473.29 kBTIFFVisualizar/Abrir
Ponte-Sucre Fig. 5.TIFFigura 567.62 kBTIFFVisualizar/Abrir

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2008 MIT and Hewlett-Packard - Comentarios