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Título : Experimental Leishmaniasis: The glibenclamide-triggered decrease in parasite growth correlates with changes in macrophage features.
Autor : Ponte-Sucre, Alicia
Figarella, Katherine
Moll, Heidrun
Palabras clave : Macrophages
Infectivity
Glibenclamide
Fecha de publicación : 28-Aug-2012
Citación : Inmunopharmacology and Immunotoxicology;23: 477-486, 2001
Resumen : Previous studies from our laboratories revealed the susceptibility of Leishmania sp. to glibenclamide (GLIB), a potassium channel blocker which selectively interacts with adenosine-binding-cassette transporters. In the present work, we analyzed whether the drug sensitivity of intracellular amastigotes correlates with changes in macrophage features that are related to their function as antigen-presenting cells. We provide evidence that in BALB/c murine macrophages, GLIB induced a decrease in the interferon-gamma-stimulated expression of major histocompatibility complex class II molecules and the co-stimulatory molecule CD86 (B7-2). Furthermore, it caused a decrease in the interleukin-1 secretion by macrophages. The data indicate that the treatment with GLIB inhibits the Th2 development and polarizes macrophage functions towards the induction of a protective Th1 response.
URI : http://saber.ucv.ve/123456789/1711
ISSN : 0892-3973
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