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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/123456789/16987

Título : Prevalence of HPV and EBV infection and their relationship with the p53 and PCNA expression in oral carcinoma patients.
Autor : Veitía, Dayahindara
Liuzzi, Juan
Ávila, Maira
De Guglielmo, Zoraya
Correnti, Maria
Palabras clave : CARCINOMA
VPH
VEB
P53
PCNA
Fecha de publicación : 2-Nov-2017
Resumen : Abstract: Introduction: Infection caused by potentially oncogenic viruses, such as HPV and EBV, favors the role of certain oncoproteins that can induce dysplasias and malignant lesions. Objective: To evaluate the prevalence of HPV and EBV and their relation with the expression of p53 and PCNA in patients with oral carcinoma. Methodology: Twenty-seven oral squamous cell carcinomas (OSCC) were evaluated; DNA extraction was conducted using the QIAamp DNA mini kit; viral detection was obtained using the INNO-LiPA kit for HPV, and nested PCR was used for EBV. The evaluation of molecular markers was performed through immunohistochemical staining. Results: The mean age of the patients was 60.55±13.94 years, and 52% of these were female. Of the patients, 59% were tobacco users and 63% were alcohol consumers. HPV was detected in 70% of the patients with the predominance of genotype 16 (60%). As for EBV infection, it was observed in 59% of cases. p53 and PCNA immunopositivity corresponded to 44% and 59%, respectively. The tongue was the anatomical location with highest positivity for both viruses as well as for the expression of molecular markers. The 48% of the cases presented infection by both viruses. Conclusion: HPV and EBV infection together with the expression of p53 and PCNA were more frequently observed in advanced stages of the disease, suggesting a more relevant role in the progression than in tumor genesis.
URI : http://hdl.handle.net/123456789/16987
ISSN : 0719-2479
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