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Título : Leishmania sp.: Proficiency of drug-resistant parasites
Autor : Natera, Sonimar
Machuca, Claudia
Padron-Nieves, Maritza
Romero, Amarilis
Díaz, Emilia
Ponte-Sucre, Alicia
Palabras clave : cost of adaptation
Leishmania
glucose uptake
infectivity
metabolic adaptation
Fecha de publicación : 23-Aug-2012
Citación : International Journal of Antimicrobial Agents;29: 637-42, 2007
Resumen : Leishmaniasis is a disease caused by at least 17 different species of protozoan Leishmania parasites, and currently affects around 12 million people living mostly in tropical and subtropical areas. Failure to successfully treat leishmaniasis is often due to drug resistance. However, there are no cellular and molecular markers of chemo-resistance against leishmanicidal drugs, and the only reliable method for monitoring resistance of individual isolates is the in vitro amastigote-macrophage model. It is thus necessary to find cellular and molecular markers that can be used systematically to identify the drug-resistant phenotype of the infecting parasites. Until now, whether drug resistance in Leishmania compromises the parasite proficiency, e.g. in terms of infectivity or metabolism, has not been systematically evaluated. Therefore, here we examine whether the physiological changes expressed by drug-resistant Leishmania reflect a modification of parasite vitality in drug-resistant compared to drug-sensitive parasites. Finally, the clinical implications of drug resistance in Leishmania are also discussed.
URI : http://saber.ucv.ve/123456789/1696
ISSN : 0924-8579
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