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Título : Cutaneous carcinosarcoma and the EMT: to transition, or not to transition? That is the question
Autor : Paniz-Mondolfi, Alberto
Singh, Rajesh
Jour, George
Mahmoodi, Mandana
Diwan, A. Hafeez
Barkoh, Bedia A.
Cason, Ronald
Huttenbach, Yve
Benaím, Gustavo
Galbincea, John
Luthra, Rajyalakshmi
Palabras clave : epithelial-mesenchymal transition
(EMT)
molecular mechanisms
cell adhesion
gene expression
mesenchymal-like cells
Fecha de publicación : 2015
Editorial : Virchows Arch
Citación : Vol. 466;No. 3 pp 359–360
Resumen : To the editor: We thank Dr. Zidar and Dr. Gale for their timely and detailed comments on our paper [1]. Indeed, epithelial-mesenchymal transition (EMT) is a multifaceted process driven by an intricate network of molecular mechanisms which to date remain incompletely understood, due to the extraordinary complexity of their regulation [2]. These processes include changes in cell adhesion and shape, gene expression, and extensive cross-talk between signaling pathways that create complex biochemical networks [2, 3], of which the final result in cancer is the development of mesenchymal-like cells with enhanced capacity for invasion, migration, and dissemination[3].
Descripción : A. Paniz-Mondolfi : A. H. Diwan : Y. Huttenbach Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA A. Paniz-Mondolfi (*) Departments of Biochemistry and Dermatopathology (SAIB/IVSS), Hospital Internacional& Universidad de Los Andes (ULA), Caracas/ Barquisimeto/Mérida, Venezuela e-mail: albertopaniz@yahoo.com R. Singh : B. A. Barkoh : R. Cason : J. Galbincea : R. Luthra Molecular Diagnostics Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX, USA G. Jour Department of Anatomic Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA G. Jour Department of Pathology, Memorial Sloan Kettering, Cancer Center, New York, NY, USA M. Mahmoodi Department of Dermatopathology, Miraca Life Sciences Research Institute & Tufts University School of Medicine, Boston, MA, USA G. Benaim Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Venezuela A. Paniz-Mondolfi Department of Pathology and Laboratory Medicine, Laboratorio de Bioquímica, (SAIB/IVSS), Hospital Internacional de Barquisimeto, Avenida Intercomunal Barquisimeto–Cabudare con Avenida La Montañita, Urb. Las Mercedes, Cabudare, Estado Lara, Venezuela.
URI : http://hdl.handle.net/123456789/15675
ISSN : 1432-2307 (Electronic)
0945-6317 (Linking)
0945-6317 (Print)
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