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Título : Characterization of local memory cells in stage-classified pulmonary tuberculosis: preliminary observations.
Autor : URDANETA, E .
FEO-FIGARELLA, E.
MONTALVO, C.
TÁLAMO, C.
CASTILLO, Y.
CARRASCO, D.
RIVERA, H.
BLANCA, I.
MACHADO, I.
ECHEVERRÍA DE PÉREZ, G.
DE SANCTIS, J. B.
BIANCO COLMENARES, NICOLÁS E.
Palabras clave : Local Memory Cells
Pulmonary Tuberculosis
Immunophenotype
Bronchoalveolar lavage
DPI
LPI
Lymphocyte infiltration
purified protein derivative
peripheral blood monocytes
Mycobacterium tuberculosis
Fecha de publicación : 1998
Editorial : Scandinavian journal of immunology
Citación : Vol. 47;No. 5 pp 496-501
Resumen : Immunophenotype analysis and proliferative responses were investigated in bronchoalveolar lavage (BAL) cells from 21 patients with stage-classified tuberculosis: six with localized pulmonary infiltrate (LPI); seven with diffuse pulmonary infiltrate (DPI); and eight with pleural effusions (PE). Bronchoalveolar lavage cells from these patients contained a high number of cells/ml. The macrophage number was significantly lower in the DPI group (P < 0.05) compared to the LPI or PE groups. Conversely, neutrophils were markedly increased in DPI patients compared to LPI (P < 0.01) and PE (P < 0.01) patients. Lymphocyte infiltration (97.7 +/- 2.3% CD3+, > 83% αβ+ and CD4+ > CD8+) was observed in the three groups. A significant increase in the number of total lymphocytes (P < 0.01) and CD4+ cells (P < 0.05) was observed in the LPI group compared to the PE group. In the LPI group CD4+CD45RO+ cell infiltration was higher than CD4+CD45RA+ cells (P < 0.001), contrasting to similar numbers of these subpopulations in the DPI group. Lymphocytes from three out of three LPI patients (αβ+CD4+CD45RO+) responded against tuberculin purified protein derivative contrasting to the unresponsiveness of five patients with either DPI or PE. This impaired response was reverted in two out of five patients by using peripheral blood monocytes instead of alveolar macrophages. It is suggested that, in humans, αβCD4+CD45RO cells are the main lymphocyte type involved in the initial local cell-mediated immune response against Mycobacterium tuberculosis.
URI : http://hdl.handle.net/123456789/14883
ISSN : 1365-3083
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