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Título : Increased peroxide production by polymorphonuclear cells of chronic hepatitis C virus-infected patients.
Autor : Toro, Felix
Conesa, Angela
Garcia, Alexis
Bianco Colmenares, Nicolás E.
De Sanctis, Juan B.
Palabras clave : polymorphonuclear cells
hepatitis C virus infection
peroxide production
flow cytometry
intracellular hydrogen
production of polymorphonuclear
Fecha de publicación : Aug-1998
Citación : Vol. 88;No. 2 pp 169-175
Resumen : To evaluate the oxidative burst in hepatitis C virus (HCV) infection, intracellular hydrogen peroxide (H202) production of polymorphonuclear (PMN) cells isolated from 15 chronic HCV-infected patients and 11 controls was assessed by flow cytometry in a time kinetic. Under nonstimulated and phorbol myristate acetate (PMA)-stimulated conditions, H202 production was higher in HCV-infected patients than in controls (P <0.05) at the time points of 20, 30, and 40 min. A positive correlation between H202 production by PMA-stimulated cells and serum levels of alanine aminotransferase and aspartate aminotransferase was found in the HCV-infected patients (r = 0.877, P <0.01 and r = 0.9351, P <0.001, respectively). RT-PCR analysis of purified mononuclear (MN) and PMN cells from HCV-infected patients revealed the presence of HCV RNA in 60% of MN and 27% of PMN cell samples. These results suggest that a functional alteration of PMN cells is manifested in this chronic viral infection which may represent an additional factor in the development of liver lesions.
ISSN : 0090-1229
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