SABER UCV >
1) Investigación >
Artículos Publicados >
Por favor, use este identificador para citar o enlazar este ítem:
|Título : ||T Cell Hyperreactivity to IL-6 in Chronic Nonviremic HBV Carriers Despite Normal IL-6 Receptor or gp130 Expression|
|Autor : ||BAROJA, MIREN L.|
SIRIT, FIRELEI L.
BIANCO COLMENARES, NICOLÁS E.
MACHADO, IRMA V.
|Palabras clave : ||chronic nonviremic|
T Cell Hyperreactivity
hyperreactive to monocyte
PHA-stimulated T celis
|Fecha de publicación : ||1996|
|Editorial : ||VIRAL IMMUNOLOGY|
|Citación : ||Vol. 9;No.3 pp 187-194|
|Resumen : ||We previously showed that T cells from chronic nonviremic HBsAg carriers activated with immobilized OKT3 MAb are hyperreactive to monocyte accessory signals, mainly to interleukin-6 (IL-6). We have further characterized this T cell hyperreactivity using phytohemagglutinin (PHA) as the primary activating signal. PHA-stimulated T cells from nonviremic patients had a significantly higher response to addition of monocytes, monocyte supernatants, and IL-6 alone or combined with IL-1β when compared to controls. We examined if these effects could be mediated by a differential expression of IL-6 receptor (p80) or gp130 on resting or PHA-stimulated T cells. We found that PHA, IL-6, IL-1β or IL-2 induced only small changes of the dull p80 expression on T cells. In contrast, we found a significant increase of gp130 expression on PHA-activated T cells compared to unstimulated T cells, which was down-regulated by the presence of IL-6. However, no significant differences in p80 or gp130 expression were detected between patients and controls within all the culture conditions tested. Our results confirm that IL-6 is involved in the in vitro T cell hyperreactivity of nonviremic HBV carriers and indicate that this effect is not mediated by disturbances of IL-6 receptor expression.|
|URI : ||http://hdl.handle.net/123456789/14677|
|ISSN : ||1557-8976|
|Aparece en las colecciones: ||Artículos Publicados|
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.