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Título : Expression of different lipoprotein receptors in natural killer cells and their effect on natural killer proliferative and cytotoxic activity
Autor : DE SANCTIS, J. B.
BLANCA, I.
BIANCO COLMENARES, NICOLÁS E.
Palabras clave : Natural killer
cells chylomicrons
lipoproteins
VLDL
HDL
LDL
anti-LDL
lipoproteins assessed
Fecha de publicación : 1995
Editorial : Immunology
Citación : Vol. 86;No. 3 pp 399-407
Resumen : Natural killer (NK) cells take up chylomicrons (CM), very low density (VLDL), low density (LDL), high density (HDL) and acetyl-modified low density (AcLDL) lipoproteins through different receptors, VLDL being the lipoprotein with the highest uptake and HDL the lowest. The uptake of LDL can be selectively blocked by the anti-LDL receptor, which does not affect the uptake of CM, VLDL, HDL and AcLDL. Although the uptake of lipoproteins assessed by flow cytometry using DiI is not very high, the lipoproteins are able to induce an increase in proliferative responses, VLDL, AcLDL and HDL being the most important ones with 12- and 17-fold increments, respectively. CM, VLDL and LDL at low concentrations increase NK cytotoxic activity, while HDL and AcLDL inhibit, in a dose-dependent fashion, the killing of NK cells against K562. These results suggest the presence of four different receptors that are responsible for the cytotoxic and proliferative responses observed.
URI : http://hdl.handle.net/123456789/14545
ISSN : 1365-2567
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