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Título : CD3- and CD28-Activating Pathways in HCV Infection
Autor : CORADO, JOSÉ A.
TORO, FELIX I.
BAROJA, MIREN L.
BIANCO COLMENARES, NICOLÁS E.
MACHADO, IRMA V.
Palabras clave : CD3-
CD28-
mononuclear cells
hepatitis C virus
viremia
low cytometry
HCV-infected
activa liver disease
Fecha de publicación : 1994
Editorial : VIRAL IMMUNOLOGY
Citación : Vol. 7;No. 1 pp 37-40
Resumen : We investigated the proliferative response and IL-2 receptor (IL-2R) expression in peripheral blood mononuclear cells (PBMC) activated with anti-CD3 mAb alone or in combination with anti-CD28 mAb in a group of hepatitis C virus (HCV)-infected patients with detectable viremia demonstrated by "nested" PCR. PBMC from HCV patients and controls showed similar proliferative responses either to anti-CD3 mAb, 64.1, and/or to anti-CD28 mAb, 9.3. No differences were found in anti-CD3 or anti-CD3 plus anti-CD28-induced proliferative responses between patients who demonstrated circulating PBMC bearing HCV-RNA when compared to those with negative HCV-RNA PBMC. Moreover, flow cytometry studies confirmed that anti-CD3 alone or in combination with anti-CD28 were able to induce a significant increase of IL-2R expression in patients or controls PBMC. Both groups showed similar basal CD28 expression. These results indicate that both CD3- and CD28-activating pathways are preserved in HCV-infected patients with chronic active liver disease.
URI : http://hdl.handle.net/123456789/14535
ISSN : 1557-8976
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