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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/123456789/14534

Título : Anti-CD3-Activated T Cells from Chronic Nonviremic HBV Carriers Are Hyperreactive to Monocytic Accessory Signals
Autor : BAROJA, MIREN L.
SIRIT, FIRELEI L.
CALDERA, DILIAM J.
TORO, FELIX I.
ZABALETA, MERCEDES E.
COLMENARES, CARMEN J.
BIANCO COLMENARES, NICOLÁS E.
MACHADO, IRMA V.
Palabras clave : Anti-CD3-Activated T Cells
Chronic Nonviremic HBV Carriers
Monocytic Accessory
mAb OKT3
cell cultures stimulated
monocytes
autologous monocytes
IL-6
Fecha de publicación : 1993
Editorial : CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY
Citación : Vol. 69;No. 2 pp 180-188
Resumen : We analyzed T cell responses through the CD3 activation pathway in a group of chronic HBV carriers. PBMC stimulated with the mAb OKT3 showed higher proliferative response in HBV-DNA(-) carriers compared to HBV-DNA(+) carriers and to controls. In contrast, no differences in proliferative responses were observed between HBV-DNA(-) carriers and controls in cell cultures stimulated with immobilized 64.1 mAb (SPB-64.1) which induces proliferation in the absence of monocytes. We further examined T cell responses in the presence of monocytes and their soluble factors to immobilized OKT3 mAb (SPB-OKT3). Purified T cells did not proliferate to SPB-OKT3. When autologous monocytes were added, higher proliferative response, IL-2 production, and IL-2 receptor expression were observed in HBV-DNA(-) carriers than in controls. An enhanced cell proliferation was also obtained when monocyte supernatants were added to T cells cultured with SPB-OKT3. Moreover, when IL-6 alone or combined with IL-1 was added to SPB-OKT3-stimulated T cell cultures, a significantly higher increase in T cell proliferation was detected in HBV-DNA(-) carriers. Our results thus show a T cell hyperreactivity to accessory signals from monocytes (mainly IL-6) in HBV-DNA(-) carriers, that is probably related to an ongoing viral clearance.
URI : http://hdl.handle.net/123456789/14534
ISSN : 0090-1229/93
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