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Título : Risk factors for dialysis-associated hepatitis e in Venezuela
Autor : MULLER, GRETE Y.
ZABALETA, MERCEDES E.
ARMINIO, ANABELLA
COLMENARES, CARMEN J.
CAPRILES, FREYA I.
BIANCO COLMENARES, NICOLÁS E.
MACHADO, IRMA V.
Palabras clave : Risk factors
hepatitis C
dialysis
enzyme immunoassays
C virus
hemodialysis
Fecha de publicación : Apr-1992
Editorial : Kidney lnternational
Citación : Vol. 41;No. 4 pp 1055-1058
Resumen : Risk factors for dialysis-associated hepatitis C in Venezuela. Utilizing the first and second generation of enzyme immunoassays which detect antibodies to the C virus we investigated the frequency of anti-HCV antibodies in 315 patients undergoing hemodialysis. Other subpopulations at risk were used as reference groups. One hundred and twenty-three samples (39%) from the hemodialysis group repeatedly showed anti-HCV positive antibodies while only 19% and 1% were positive in the reference groups. The rate of anti-HCV reactive patients correlated with time on hemodialysis (< 1 year, 17% 1 to 5 years 43% > 5 years, 64% r = 0.94, P < 0.001) and with the number of blood transfusions (1 to 10, 40% > 10, 76% r = 0.97; P < 0.001). Length of time on hemodialysis was shown to be the major risk factor in thirty-three anti-HCV positive patients who had no previous record of blood transfusions. Co-infection with HBV was demonstrated in 41% out of 123 anti-HCV reactive patients, and increased alanine aminotransferase (ALT) activity was documented in this co-infected group. Our results further extend the observations on the predisposing factors to HCV spread in hemodialysis units, and suggest that in these renal patients co-infection with C and B viruses is a major cause of rising ALT activity.
URI : http://hdl.handle.net/123456789/14508
ISSN : 0085-2538
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