SABER UCV >
1) Investigación >
Artículos Publicados >

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/123456789/14497

Título : Cellular Immunity in Current Active Pulmonary Tuberculosis
Autor : ANDRADE-ARZABE, RONALD
MACHADO, IRMA V.
FERNANDEZ, BEATRIZ
BLANCA, ISAAC
RAMIREZ, ROMELIA
BIANCO COLMENARES, NICOLÁS E.
Palabras clave : pulmonary TB
immunized individuals
Cellular immune mechanisms
mononuclear cells
PHA
PPD
recall antigens
adherent cells
Fecha de publicación : Mar-1991
Editorial : The American review of respiratory disease
Citación : Vol. 143;No. 3 pp 496-500
Resumen : A group of 10 patients with recently diagnosed pulmonary TB were studied and compared to 10 bacillus Calmette Guérin (BCG) immunized healthy individuals. Cellular immune mechanisms were explored in vitro utilizing fresh and precultured peripheral blood mononuclear cells exposed to PHA, PPD, and recall antigens (SK/SD and CA). Proliferative assays were also carried out in the presence of either each patient's serum (autologous serum) or cocultured with CD3+ depleted adherent cells. Serum measurements of soluble interleukin-2 (IL-2) receptor and synthesis of IL-2 generated by mononuclear cells stimulated with PPD and SK/SD were also performed. Patient sera were able to inhibit autologous as well as allogeneic cell responses, and a significant adherent cell suppressive effect was observed. As a whole the group of patients showed decreased blast transformation to PPD, preserved proliferative responses to other recall antigens, and a low PPD-induced generation of IL-2. Furthermore, as possible evidence of preactivated T cells, these patients demonstrated high soluble IL-2 receptor serum levels. Early compromise of specific cell-mediated immunity, including IL-2 abnormalities, may be of significance in newly diagnosed pulmonary TB.
URI : http://hdl.handle.net/123456789/14497
ISSN : 0003-0805
Aparece en las colecciones: Artículos Publicados

Ficheros en este ítem:

Fichero Descripción Tamaño Formato
Documento 47.pdf12.81 MBAdobe PDFVisualizar/Abrir

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2008 MIT and Hewlett-Packard - Comentarios