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Título : Immunopathogenic Aspects of Infection by the Human Immunodeficiency Virus in Venezuela.
Autor : ECHEVERRIA DE PÉREZ, GLORIA
DEIBIS, LEOPOLDO
GARCÍA, SILVIA
OLARIA, TANIA
MÁRQUEZ, MERLY
BLANCA, ISAAC
BIANCO COLMENARES, NICOLÁS E.
Palabras clave : immunopathogenic characteristics
HIV infection
Clinical Immunology
CD4 cells
granular lymphocytes
cytotoxic activity
Fecha de publicación : 1989
Editorial : Bulletin of the Pan American Health Organization journal (Bull Pan Am Health Organ).
Citación : Vol. 23;No. 1-2 pp 68-75
Resumen : A study of the immunopathogenic characteristics of HIV infection was begun in 1984 at the National Reference Center on Clinical Immunology (CNRIC) in Caracas, Venezuela, on 240 individuals with a variety of clinical manifestations. The most important findings were depletion of the CD4 cells in HIV- infected individuals, including asymptomatic carriers; significant reduction of the C03-, C016+ large granular lymphocytes (LGL) in AIDS cases; decrease in LGL cytotoxic activity in infected persons versus controls, along with increased lytic function induced by stimulation with recombinant interleukin-2 in both groups; and reduction of the C04 population in AIDS patients, independent of the presence or absence of free serum antigen. Such research is helping to clarify the immunopathogenic mechanisms of HIV and possible geographic and demographic variations.
URI : http://hdl.handle.net/123456789/14489
ISSN : 1680-5348
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