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Título : Helper Activity by Human Large Granular Lymphocytes in in Vitro Immunoglobulin Synthesis
Autor : RODRIGUEZ, MARTIN A.
BLANCA, ISAAC
BAROJA, MIREN L.
ARAMA, SIMY
LEON-PONTE, MATILDE
ABADI, ISAAC
Bianco Colmenares, Nicolás E.
Palabras clave : Large granular lymphocytes
B lymphocytes
immunoglobulin synthesis
helper Iymphocyte function
mitogen-activated
LGL
Fecha de publicación : 1987
Editorial : Journal of Clinical lmmunology
Citación : Vol. 7;No. 5 pp 356-364
Resumen : In the present study we have examined the effect of human large granular Iymphocytes (LGL) from health y donors on Ig synthesis by autologous B Iymphocytes. The results showed that this cell population has a consistent helper activity in pokeweed mitogen-activated cultures even when added at very low numbers. LGL can mediate their effect by secreting soluble helper factors capable of modulating B-cell responses as evidenced by the enhancement of IgG and IgM production by supernatants obtained from LGL cultures. Preincubation with interferon gamma further potentiated the helper activity by LGL.
URI : http://hdl.handle.net/123456789/14421
ISSN : 1573-2592
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