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Título : Biological screening of plants of the Venezuelan Amazons
Autor : Jiménez, G.
Hasegawa, Masahisa
Rodríguez, María del C.
Estrada, Omar
Méndez, Jeannette
Castillo, Anibal
González-Mujica, F.
Motta, N.
Vásquez, J.
Romero-Vechione, Eduardo
Palabras clave : Amazonian plants
Brine shrimp lethality test
Cardiovascular activity
Glucose-6-phosphatase
Biological screening
Fecha de publicación : 2001
Editorial : Journal of Ethno-Parmacology
Citación : Journal of Ethnopharmacology 77 (2001) 77–83
Resumen : A total of 21 extracts derived from 17 different plant species collected in Venezuelan Amazons have been tested for the following biological activities: cardiovascular activity, brine shrimp lethality, and inhibitory effects on the hydrolysis of glucose-6-phosphate in intact and disrupted microsomes. Eight extracts diminished rat blood pressure with or without changes in heart rate. The fruit extract of Swartzia leptopetala and the leaf and twig extract of Connarus lambertii resulted in death of experimental animals. The majority of extracts (17 extracts) showed significant toxicity against Artemia salina. Concerning the hydrolysis of glucose-6-phosphate, better inhibitory effects were observed in intact microsomes than in disrupted ones for all the extracts, suggesting that these extracts intervene with variable potency in glucose-6-phosphate transport through the microsomal membrane.
URI : http://hdl.handle.net/123456789/14063
ISSN : 0022-3573
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