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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/123456789/14057

Título : (6R,9S)-6′′-(4′′-Hydroxybenzoyl)-Roseoside, a New Megastigmane Derivative from Ouratea polyanthaand its Effect on Hepatic Glucose-6-phosphatase
Autor : Bermúdez, Jairo
Rodríguez, María del C.
Hasegawa, Masahisa
González-Mujica, Freddy
Duque, Sandra
Ito, Yoichiro
Palabras clave : Agathisflavone
Countercurrent chromatography
Glucose-6-phosphatase
Megastigmanes
Ouratea polyantha
Terpenes
(6R,9S)-6′-(4′′- Hydroxybenzoyl)-roseoside
Fecha de publicación : 2012
Editorial : Natural Product Communications
Citación : Volumen 7, Número 8, páginas 1-4
Resumen : A new megastigmane derivative, (6R,9S)-6′-(4′′-hydroxybenzoyl)-roseoside(1)and two known compounds, the biflavoneagathisflavone(2) and 4- hydroxybenzoic acid (3) were isolated and purified from leaves and stems of Ouratea polyantha Engl. Agathisflavone was isolated in a single high-speed counter-current chromatography run, while the megastigmane was purified in two steps, by using a combination of high-speed countercurrent chromatography and analytical column chromatography. All structures were elucidated on the basis of spectral evidence and comparison with literature data. Compound 1 was characterized by []D 20, UV-Vis, IR, MS, 1H NMR, 13C NMR, HMQC, HMBC, COSY and NOESY. Compounds 1 and 2 showed an inhibitory effect of 63.6 and 13.7% on the G-6-Pase intact microsomes, respectively.
URI : http://hdl.handle.net/123456789/14057
ISSN : 1555-9475
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